How Does the Alarmone ppGpp Change Bacterial Cell Metabolism? From Genome-wide Approaches to Structure to Physiology

Wang et  al. (2020) show that binding of the second messenger ppGpp to inosine-guanosine kinase (Gsk) in E. coli modulates the levels of the key metabolite phosphoribosyl pyrophosphate (pRpp), decreasing purine synthesis to favor amino acid synthesis during stress adaptation.

Source: Molecular Cell - September 30, 2020 Category: Cytology Authors: Anushya Petchiappan, Susan Gottesman Tags: Preview Source Type: research