Nondestructive Detection of Targeted Microbubbles Using Dual-Mode Data and Deep Learning for Real-Time Ultrasound Molecular Imaging
Ultrasound molecular imaging (UMI) is enabled by targeted microbubbles (MBs), which are highly reflective ultrasound contrast agents that bind to specific biomarkers. Distinguishing between adherent MBs and background signals can be challenging in vivo. The preferred preclinical technique is differential targeted enhancement (DTE), wherein a strong acoustic pulse is used to destroy MBs to verify their locations. However, DTE intrinsically cannot be used for real-time imaging and may cause undesirable bioeffects. In this work, we propose a simple 4-layer convolutional neural network to nondestructively detect adherent MB signatures. We investigated several types of input data to the network: “anatomy-mode” (fundamental frequency), “contrast-mode” (pulse-inversion harmonic frequency), or both, i.e., “dual-mode”, using IQ channel signals, the channel sum, or the channel sum magnitude. Training and evaluation were performed on in vivo mouse tumor data and microvessel phantoms. The dual-mode channel signals yielded optimal performance, achieving a soft Dice coefficient of 0.45 and AUC of 0.91 in two test images. In a volumetric acquisition, the network best detected a breast cancer tumor, resulting in a generalized contrast-to-noise ratio (GCNR) of 0.93 and Kolmogorov-Smirnov statistic (KSS) of 0.86, outperforming both regular contrast mode imaging (GCNR = 0.76, KSS = 0.53) and DTE imaging (GCNR = 0.81, KSS = 0.62). Further development of the me...
ConclusionThe presence of breast cancer does not significantly increase the likelihood for upgrade at a separate site of ipsilateral concurrent ADH above contemporary reported upgrade rates of ADH alone (10 –30%). When considering breast conservation for breast cancer, omitting excision of the site of ADH can be considered when low-risk features are present.
Authors: Liang X, Li Z, Zhang L, Wang D, Tian J Abstract To explore the value of contrast-enhanced ultrasound (CEUS) in the differential diagnosis of molecular subtypes of breast cancer. Sixty-two cases of breast cancer were divided into luminal epithelium A or B subtype (luminal A/B), Her-2 over-expression subtype and triple negative subtype (TN). CEUS and routine ultrasonography were performed for all patients before surgery. (1) The luminal epithelium subtype contrast enhancement pattern was more likely to present with radial edge (76.92%, p
CONCLUSION: The probability of nodal positivity after neoadjuvant chemotherapy was less than 3 per cent in patients with TNBC or HER2-positive disease who achieved a breast rCR on MRI. These patients could be included in trials investigating the omission of sentinel node biopsy after neoadjuvant chemotherapy. PMID: 33031572 [PubMed - as supplied by publisher]
The objective of this study was to compare the effect of ultrasound-guided percutaneous MWA and NSM for breast cancer.Materials and MethodsA retrospective cohort study was conducted in a single institution from 2014 to 2020. Women with invasive ductal carcinoma of the breast ≤ 5cm treated by MWA or NSM were enrolled. The primary end point was tumor progression and secondary end points included survival, cosmetic results, and complications.Results21 patients in the MWA group and 43 in the NSM group were evaluated. The mean tumor size was 2.3 cm (range, 0.3–5.0 cm). Median follow-up was 26.7 months (range, 14.6...
Conclusion: Automated breast ultrasound is expected to overcome some of the major limitations of conventional ultrasound in breast cancer screening. In Brazil, this new method can be accepted for inclusion in routine clinical practice only after its advantages have been validated in the national context.Resumo Objetivo: O objetivo deste estudo foi avaliar as principais limita ções técnicas e a porcentagem de exames excluídos de ultrassonografia automatizada. Materiais e Métodos: Foram realizados 440 exames de ultrassonografia automatizada das mamas no período 12 meses, por té...
Background: Breast conservation (BCS) is the standard surgical procedure for early breast cancer. It is a challenge for surgeons to achieve adequate excision of lesion with clear margins and acceptable cosmesis. To remove precisely the volume of tissue required, continuous intra-operative ultrasound (IOUS) had been used during BCS. We reviewed its effectiveness to obtain clear margins, low excision volume and better cosmetic outcome.
Background: Accurate axillary assessment prior to NACT is important for treatment planning. De-escalation of axillary surgery after NACT in patients with pre-treatment lymph node (LN) metastases is becoming more widespread but there are concerns about patient selection. CEUS can be used to augment conventional B-mode ultrasound and improve metastatic LN detection.
Background: For tumour location and surgical planning physicians need to convert 2-D information into a 3D approach. Wire guided surgery is the most common method for preoperative localization of breast cancer lesions. Other localization methods can also be used, such as radioactive seeds, carbon tattooing or ultrasound guided clips, but they are all invasive procedures. In this work, we aimed at building an individualized 3D digital breast model integrating the breast torso and tumor location through MRI/3D fusion algorithms to help in pre-operative tumour location without the use of invasive procedures.
Background: Identifying residual disease in the axilla after neoadjuvant treatment (NAT) is important to select patient for sparing an axillary node dissection (ALND). Controversy exists on the optimal number of sentinel nodes (SLNs) needed to excise along with the axillary clipped node. The aim of the study is to assess the false negative rates (FNR) in the SLN after NAT and to refine the axillary surgery using intraoperative ultrasound (IOUS) for excising axillary clipped nodes as a part of axillary staging after NAT.
Background: Magnetic resonance imaging (MRI) is used selectively in addition to digital breast tomosynthesis (DBT), ultrasound (US) and computed tomography (CT) in the preoperative assessment of breast cancer patients. The aim of this study was to evaluate the preoperative size assessment of invasive ductal carcinoma (IDC) on DBT, MRI, US, and CT compared with final histology, and evaluate the impact of MRI on the type of surgery and extent of treatment.