Controlled drug release for inflammatory bowel disease (IBD).
Controlled drug release for inflammatory bowel disease (IBD).
Bioinformation. 2020;16(7):513-524
Authors: Asha D, Jeganath S, Bupesh G, Sahoo UK, Bhaskar M, Pandian K
Abstract
Controlled drug release in formulation is an important area of research. Formulations using crospovidone as super-disintegrants to achieve immediate release once it reaches the ileo- cecal region is relevant. The Eudragit L30D pH dependent polymer that allows drug release after a lag time of 4-5 hrs to achieve desired drug release from the drug delivery system is critical. Hence, pre-formulation to study drug-polymer interaction is essential. The linear correlation between the predicted and actual values for all the batches of optimization is shown with high correlation coefficient (r-value). Therefore, the designed formulation is promising for ileo-cecal targeted pulsatile drug delivery system in the management of Crohn's disease.
PMID: 32994676 [PubMed]
Source: Bioinformation - Category: Bioinformatics Authors: Asha D, Jeganath S, Bupesh G, Sahoo UK, Bhaskar M, Pandian K Tags: Bioinformation Source Type: research