Evolutionary ecology of Lyme Borrelia.

Evolutionary ecology of Lyme Borrelia. Infect Genet Evol. 2020 Sep 27;:104570 Authors: O'Keeffe KR, Oppler ZJ, Brisson D Abstract The bacterial genus, Borrelia, is comprised of vector-borne spirochete species that infect and are transmitted from multiple host species. Some Borrelia species cause highly-prevalent diseases in humans and domestic animals. Evolutionary, ecological, and molecular research on many Borrelia species have resulted in tremendous progress toward understanding the biology and natural history of these species. Yet, many outstanding questions, such as how Borrelia populations will be impacted by climate and land-use change, will require an interdisciplinary approach. The evolutionary ecology research framework incorporates theory and data from evolutionary, ecological, and molecular studies while overcoming common assumptions within each field that can hinder integration across these disciplines. Evolutionary ecology offers a framework to evaluate the ecological consequences of evolved traits and to predict how present-day ecological processes may result in further evolutionary change. Studies of microbes with complex transmission cycles, like Borrelia, which interact with multiple vertebrate hosts and arthropod vectors, are poised to leverage the power of the evolutionary ecology framework to identify the molecular interactions involved in ecological processes that result in evolutionary change. Using existing data, we outline how ev...
Source: Infection, Genetics and Evolution - Category: Genetics & Stem Cells Authors: Tags: Infect Genet Evol Source Type: research

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CONCLUSIONS: Clinical and topical variants and forms of EF in children are associated with etiology, have different rates of complications, the nature of the course and outcomes, the knowledge of which makes it possible to optimize the diagnostic process.PMID:35038852 | DOI:10.17116/jnevro202112111286
Source: Herpes - Category: Infectious Diseases Authors: Source Type: research
Vaccine. 2022 Jan 13:S0264-410X(22)00006-8. doi: 10.1016/j.vaccine.2022.01.003. Online ahead of print.ABSTRACTVaccination guidelines for dogs and cats indicate that core vaccines (for dogs, rabies, distemper, adenovirus, parvovirus; for cats, feline parvovirus, herpes virus-1, calicivirus) are essential to maintain health, and that non-core vaccines be administered according to a clinician's assessment of a pet's risk of exposure and susceptibility to infection. A reliance on individual risk assessment introduces the potential for between-practice inconsistencies in non-core vaccine recommendations. A study was initiated t...
Source: Herpes - Category: Infectious Diseases Authors: Source Type: research
Conclusion: This systematic review, including all reported cases and our case report, supports evidence of ocular infection ofBorrelia species. Furthermore, in case of suspicion of infection and seronegativity, it is justified to look forBorrelia in eye tissue samples. In addition, microscopy without using PCR is not sufficient to confirm the diagnosis of borreliosis on ocular tissue. In the articles studied, there was no unambiguous recommendation of treatment.Ophthalmic Res
Source: Ophthalmic Research - Category: Opthalmology Source Type: research
Neurol Sci. 2022 Jan 10. doi: 10.1007/s10072-022-05865-8. Online ahead of print.ABSTRACTA 35-year-old Caucasian woman presented an abrupt onset of bilateral impaired vision, and arrived to our attention two weeks later. She had a previous episode of mild dizziness. She underwent a fluorescein angiography showing branch retinal artery occlusions and a brain magnetic resonance imaging (MRI) revealing several supraand infratentorial FLAIR-hyperintense white matter lesions, two with contrast enhancement. Thrombophilic, autoimmune and infective (including Human Immunodeficiency Virus, Borrelia burgdorferi, Hepatitis B Virus, He...
Source: Herpes - Category: Infectious Diseases Authors: Source Type: research
Br J Dermatol. 2022 Jan 6. doi: 10.1111/bjd.20977. Online ahead of print.NO ABSTRACTPMID:34990013 | DOI:10.1111/bjd.20977
Source: The British Journal of Dermatology - Category: Dermatology Authors: Source Type: research
This study identified and utilized isolates deficient in PFam54 to associate the defects with the absence of these proteins, building the foundation to further study the role of each PFam54 protein in contributing to Bbsl pathogenesis. Importance To establish infections, Lyme borreliae utilize various means to overcome the host's immune system. Proteins encoded by the PFam54 gene array play a role for spirochete survival in vitro and in vivo. Moreover, this gene array has been described in all currently available Lyme borreliae genomes. By investigating the first two Borrelia bavariensis isolates naturally lacking the enti...
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Source Type: research
Appl Environ Microbiol. 2022 Jan 5:aem0239121. doi: 10.1128/aem.02391-21. Online ahead of print.ABSTRACTIn the northeastern United States, the emergence of Lyme disease has been associated, in part, with the increase of small forest patches. Such disturbed habitat is exploited by generalist species, such as white-footed mice, which are considered the host with the greatest reservoir capacity for the agents of Lyme disease (Borrelia burgdorferi sensu stricto) and human babesiosis (Babesia microti). Spatial risk analyses have identified edge habitat as particularly risky. Using a retrotransposon-based quantitative PCR assay ...
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Source Type: research
This study identified and utilized isolates deficient in PFam54 to associate the defects with the absence of these proteins, building the foundation to further study the role of each PFam54 protein in contributing to Bbsl pathogenesis. Importance To establish infections, Lyme borreliae utilize various means to overcome the host's immune system. Proteins encoded by the PFam54 gene array play a role for spirochete survival in vitro and in vivo. Moreover, this gene array has been described in all currently available Lyme borreliae genomes. By investigating the first two Borrelia bavariensis isolates naturally lacking the enti...
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Source Type: research
Appl Environ Microbiol. 2022 Jan 5:aem0239121. doi: 10.1128/aem.02391-21. Online ahead of print.ABSTRACTIn the northeastern United States, the emergence of Lyme disease has been associated, in part, with the increase of small forest patches. Such disturbed habitat is exploited by generalist species, such as white-footed mice, which are considered the host with the greatest reservoir capacity for the agents of Lyme disease (Borrelia burgdorferi sensu stricto) and human babesiosis (Babesia microti). Spatial risk analyses have identified edge habitat as particularly risky. Using a retrotransposon-based quantitative PCR assay ...
Source: Applied and Environmental Microbiology - Category: Microbiology Authors: Source Type: research
CONCLUSION. The number of requested B. burgdorferi serological tests was highest in primary care. A clear guideline describing how to diagnose LA is needed in primary and secondary care alike. FUNDING none. TRIAL REGISTRATION Under current Danish law, no formal ethical approval was required for this study. Approval for this study was obtained from the Danish Data Protection Agency (no. 2012-58-0004).PMID:34983732
Source: Danish Medical Journal - Category: General Medicine Authors: Source Type: research
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