[Epigallocatechin gallate induces CHD5 gene demethylation to promote acute myeloid leukemia cell apoptosis in vitro by regulating p19Arf-p53-p21Cip1 signaling pathway].
CONCLUSIONS: EGCG reduces hypermethylation of CHD5 gene in KG-1 and THP-1 cells by downregulating DNMT1 to restore its expression, which results in upregulated expressions of p19Arf, p53 and p21Cip1 and induces cell apoptosis.
PMID: 32990229 [PubMed - in process]
Source: Journal of Southern Medical University - Category: Universities & Medical Training Authors: Wu M, Jiang M, Xue M, Li Q, Cheng B, Huang M, Xu L, Zhang Y Tags: Nan Fang Yi Ke Da Xue Xue Bao Source Type: research
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