Coupling antibiotics with stem cells to fight off bone infections

(Kanazawa University) Researchers from Kanazawa University investigated the effects of adipose-derived stem cells (ADSCs) loaded with the antibiotic ciprofloxacin on osteomyelitis caused by implants. By administering ADSC-loaded ciprofloxacin to the site of bone infection in rats, the researchers found a significant improvement of the infection, as shown by reduced soft tissue swelling, abscess formation, and bone degradation. These findings suggest a potential new therapy for implant-related bone infections that have traditionally been difficult to treat with antibiotics.
Source: EurekAlert! - Infectious and Emerging Diseases - Category: Infectious Diseases Source Type: news

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ConclusionThe loss of the ZF-domain and the impaired T cell proliferation accompanied by almost complete persistence of na ïve T cells despite severe infections are suggestive for a profound immunodeficiency. Allogenic HSCT should be considered early for these patients before chronic sequelae occur.
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
Abstract Despite of technical advancements in design and development of new biomaterials, device-related infections continue to occur and can be life-threatening. Differing from existing research work pertaining to introducing antibacterial function upon device surface, this study attempts to address such germ-infection issues through controlled release of antibacterial species from bulk gallium (Ga) and strontium (Sr) containing magnesium (Mg) alloys. To validate such a conceptual framework, Mg alloys containing micro-level concentrations of Ga and/or Sr (0.1 wt%) are employed as model materials, along with com...
Source: Appl Human Sci - Category: Physiology Authors: Tags: Mater Sci Eng C Mater Biol Appl Source Type: research
Publication date: November 2019Source: Materials Science and Engineering: C, Volume 104Author(s): Zhihan Gao, Mingshi Song, Rui-Liang Liu, Yongshuai Shen, Liam Ward, Ivan Cole, Xiao-Bo Chen, Xinchun LiuAbstractDespite of technical advancements in design and development of new biomaterials, device-related infections continue to occur and can be life-threatening. Differing from existing research work pertaining to introducing antibacterial function upon device surface, this study attempts to address such germ-infection issues through controlled release of antibacterial species from bulk gallium (Ga) and strontium (Sr) contai...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In this study, multifunctional bone scaffolds composed of polyurethane (PU) scaffold loaded with nano-hydroxyapatite (n-HA) and ciprofloxacin hydrochloride (CF) were fabricated. The composite scaffolds could release CF sustainably for at least 2 weeks and exhibited excellent antibacterial activity. The n-HA component in the scaffolds effectively promoted the proliferation and osteogenic differentiation of rat-bone-marrow-derived mesenchymal stem cells (BMSCs). Therefore, the prepared HA/PU-CF composite scaffolds are a functional candidate as space maintainer for the treatment of osteomyelitis.
Source: Materials Letters - Category: Materials Science Source Type: research
In this study, multifunctional bone scaffolds composed of polyurethane (PU) scaffold loaded with nano-hydroxyapatite (n-HA) and ciprofloxacin hydrochloride (CF) were fabricated. The composite scaffolds could release CF sustainably for at least 2 weeks and exhibited excellent antibacterial activity. The n-HA component in the scaffolds effectively promoted the proliferation and osteogenic differentiation of rat-bone-marrow-derived mesenchymal stem cells (BMSCs). Therefore, the prepared HA/PU-CF composite scaffolds are a functional candidate as space maintainer for the treatment of osteomyelitis
Source: Materials Letters - Category: Materials Science Source Type: research
In conclusion, the presence of aminolyzed PLLA-drug fibers in SF/OP hydrogel made this delivery system very promising in sustained release of vanco HCl.Graphical abstract
Source: European Polymer Journal - Category: Chemistry Source Type: research
KR-12-a5 is an analogue of the antimicrobial peptide KR-12. Both of these two agents can play key effects in the treatment of infections such as osteomyelitis. Our previous work demonstrated that the osteogenic differentiation of human bone marrow mesenchymal stem cells (HBMSCs) can be enhanced by KR-12. The present study investigated if KR-12-a5 could reverse the adverse effects of lipopolysaccharides (LPS) on HBMSC osteogenesis and the involved molecular mechanisms. We observed the proliferation, cell cycle, and apoptosis of HBMSCs in the presence of KR-12-a5 by a cell counting kit-8 assay and flow cytometry. The osteoge...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Gulcin Tezcan1, Ekaterina V. Martynova1, Zarema E. Gilazieva1, Alan McIntyre2, Albert A. Rizvanov1 and Svetlana F. Khaiboullina1,3* 1Institute of Fundamental Medicine and Biology, Kazan Federal University, Kazan, Russia 2Centre for Cancer Sciences, Faculty of Medicine and Health Sciences, University of Nottingham, Nottingham, United Kingdom 3Department of Microbiology and Immunology, University of Nevada, Reno, Reno, NV, United States Inflammation has a crucial role in protection against various pathogens. The inflammasome is an intracellular multiprotein signaling complex that is linked to pathogen sensing and...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Cosmeri Rizzato1, Javier Torres2, Elena Kasamatsu3, Margarita Camorlinga-Ponce2, Maria Mercedes Bravo4, Federico Canzian5 and Ikuko Kato6* 1Department of Translation Research and of New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy 2Unidad de Investigación en Enfermedades Infecciosas, Unidades Médicas de Alta Especialidad Pediatría, Instituto Mexicano del Seguro Social, Mexico City, Mexico 3Instituto de Investigaciones en Ciencias de la Salud, National University of Asunción, Asunción, Paraguay 4Grupo de Investigación en Biología del C&aacut...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
Conclusion In conclusion, F. keratoplasticum and F. petroliphilum were the most frequent species in this study. Amphotericin B showed lower MICs against Fusarium species whereas the antifungal azoles and the fungicide difenoconazole exhibited higher MICs against FSSC. Ethics Statement Samples were collected during routine patient care and the study was retrospective, therefore it was determined by the local Institutional Review Board of the Hospital de Clínicas, Federal University of Paraná and CAPES that ethical clearance was not indicated. Author Contributions PH, AA-H, FQ-T, and JM designed the study....
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
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