Pancreatic Angiopathy Associated With Islet Amyloid and Type 2 Diabetes Mellitus

Objectives Type 2 diabetes (T2D) is histopathologically characterized by islet amyloid and is closely connected with vascular complications. Here, we explore the presence of pancreatic angiopathy (PA) associated with islet amyloid and T2D. Methods From a total of 172 autopsy cases who had a history of T2D diagnosis, we randomly selected 30 T2D autopsy cases with islet amyloid (DA+) in comparison with islet amyloid-free (DA−) 30 T2D cases and 60 nondiabetic (ND) controls. Amyloid deposits and PA including atherosclerosis of pancreatic interlobar arteries, arterial calcification, atheroembolism, hyaline arteriosclerosis of small arterioles, and islet capillary density were detected in all groups. Results Pancreatic angiopathy was found in 91.7% of patients with T2D and in 68.3% of ND controls (P
Source: Pancreas - Category: Gastroenterology Tags: Original Articles Source Type: research