Venous Congestion, Not Cardiac Index is Associated with Diuretic Resistance

Diuretic resistance is associated with worse outcomes in acute decompensated heart failure (ADHF). Traditional dogma has held that low cardiac index (CI) is a driver of diuretic resistance by reducing renal perfusion. Recently, accumulating evidence has shown that venous congestion has a more potent effect on cardiorenal interactions than low CI. However, venous congestion also likely identifies patients with increased volume overload and the potential for a greater diuretic response.

Source: Journal of Cardiac Failure - September 30, 2020 Category: Cardiology Authors: Maxwell Eder, Matthew Griffin, James Fleming, Olyvia Gleason, Grace Meegan, Juan Ivey-Miranda, Zachary Cox, Veena Rao, Jeffrey Testani Tags: 081 Source Type: research