Vitamin D Binding Protein as a Potential Biomarker for Heart Failure in Myocarditis: Translational Animal Model Reveals Mechanism

An estimated 3.1 million cases of myocarditis/cardiomyopathy were diagnosed in 2017. Myocarditis, inflammation of the myocardium, is a leading cause of sudden death from heart failure in children and young adults worldwide. Patients can progress to dilated cardiomyopathy, heart and heart transplant. Studies have found that Vitamin D binding protein (DBP) could be instrumental in response to tissue injury and activation of the immune response. This chemotaxis activation has been shown to be due to activation of the complement cascade via C5a.
Source: Journal of Cardiac Failure - Category: Cardiology Authors: Tags: 274 Source Type: research