Mild atopic dermatitis lacks systemic inflammation, and shows reduced non-lesional skin abnormalities

Most immune genes formed a severity-dependent expression gradient in lesional/non-lesional AD. Mild/limited AD lacked the systemic abnormalities characteristic of moderate-to-severe disease, with minimal immune activation in non-lesional skin and blood.

https://www.jacionline.org/article/S0091-6749(20)31334-8/abstract?rss=yes

Source: Journal of Allergy and Clinical Immunology - September 30, 2020 Category: Allergy & Immunology Authors: Helen He, Ester Del Duca, Aisleen Diaz, Hyun Je Kim, Jes ús Gay-Mimbrera, Ning Zhang, Jianni Wu, Jessica Beaziz, Yeriel Estrada, James G. Krueger, Ana B. Pavel, Juan Ruano, Emma Guttman-Yassky Source Type: research