FOXP3rs3761548 gene variant and interleukin-35 serum levels as biomarkers in patients with multiple sclerosis.

FOXP3rs3761548 gene variant and interleukin-35 serum levels as biomarkers in patients with multiple sclerosis. Rev Neurol (Paris). 2020 Sep 25;: Authors: Kamal A, Hosny M, Abd Elwahab A, Shawki Kamal Y, Shehata HS, Hassan A Abstract BACKGROUND: Multiple sclerosis (MS) is a chronic autoimmune disease of the central nervous system (CNS). Aberrant expression of transcription factor forkhead box P3 (FoxP3) has been suggested to underlie different immunological disorders as FOXP3 expression is essential for T regulatory cells (Tregs) to maintain their suppressive and anti-inflammatory functions and exert immunologic self-tolerance. Interleukin-35 (IL-35) is an important immunosuppressive cytokine that is produced mainly by CD4+ FOXP3+ Tregs. OBJECTIVES: To assess the possible role of the FOXP3 rs3761548 (C/A) single-nucleotide variation (SNV) in relapsing-remitting multiple sclerosis (RRMS). Also, measurement of the serum IL-35 concentration and study its relation to different genotypes and the degree of disease-related disability. METHODS: A total of 100 RRMS patients and 90 healthy control subjects were subjected to genotyping for the FOXP3 (rs3761548) variant by TaqMan real-time PCR, and measurement of the IL-35 level in their sera by Elisa. RESULTS: The frequencies of the AA genotype and A allele were significantly higher in the MS patients than in the healthy controls (P=0.008, OR=2.53, 95% CI=1.27-5.04; P=0.001, OR=1.98, 95% CI=1.31-3.00, res...
Source: Revue Neurologique - Category: Neurology Tags: Rev Neurol (Paris) Source Type: research

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Source: European Journal of Medicinal Chemistry - Category: Chemistry Authors: Tags: Eur J Med Chem Source Type: research
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Source: Experimental Neurology - Category: Neurology Authors: Tags: Exp Neurol Source Type: research
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Source: International Journal of Environmental Research and Public Health - Category: Environmental Health Authors: Tags: Article Source Type: research
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Source: Roche Media News - Category: Pharmaceuticals Source Type: news
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Source: Journal of Molecular Neuroscience - Category: Neuroscience Source Type: research
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