Comparison of Isolation, Expansion and Cryopreservation Techniques to Produce Stem Cells from Human Exfoliated Deciduous teeth (SHED) with better Regenerative Potential.

Comparison of Isolation, Expansion and Cryopreservation Techniques to Produce Stem Cells from Human Exfoliated Deciduous teeth (SHED) with better Regenerative Potential. Curr Stem Cell Res Ther. 2020 Sep 28;: Authors: Lee SH, Looi CY, Chong PP, Foo JB, Looi QH, Ng CX, Ibrahim Z Abstract Mesenchymal stem cells (MSCs) are adult stem cells that are gaining worldwide attention for its multi-potential use in tissue engineering-based regenerative medicine. They can be obtained from numerous sources and one of the excellent source is from the dental tissue, such as stem cells that are extracted from the human exfoliated deciduous teeth (SHEDs). SHEDs are considered ideal due to its inherent characteristics, including the capability to proliferate quickly with minimal oncogenesis risk, multipotency capacity and its ability to suppress the immune system. On top of these positive cell traits, SHEDs are easily accessible with patient's safety assured, posing less ethical issues and could also provide sufficient cells number for prospective clinical uses. This is primarily attributed to its ability to differentiate into multiple cell linages, including osteoblasts, odontoblasts, neuronal cells, adipocytes, as well as endothelial cells. Albeit SHEDs having a bright future, there still remains an obstacle to develop reliable experimental techniques to retain the long term regeneration potential of the stem cells for prospective research and clinic...
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Curr Stem Cell Res Ther Source Type: research