Cancers, Vol. 12, Pages 2817: Translating Biomarkers of Cholangiocarcinoma for Theranosis: A Systematic Review

Cancers, Vol. 12, Pages 2817: Translating Biomarkers of Cholangiocarcinoma for Theranosis: A Systematic Review Cancers doi: 10.3390/cancers12102817 Authors: Imeshi Wijetunga Laura E. McVeigh Antonia Charalambous Agne Antanaviciute Ian M. Carr Amit Nair K. Raj Prasad Nicola Ingram P. Louise Coletta Cholangiocarcinoma (CCA) is a rare disease with poor outcomes and limited research efforts into novel treatment options. A systematic review of CCA biomarkers was undertaken to identify promising biomarkers that may be used for theranosis (therapy and diagnosis). MEDLINE/EMBASE databases (1996–2019) were systematically searched using two strategies to identify biomarker studies of CCA. The PANTHER Go-Slim classification system and STRING network version 11.0 were used to interrogate the identified biomarkers. The TArget Selection Criteria for Theranosis (TASC-T) score was used to rank identified proteins as potential targetable biomarkers for theranosis. The following proteins scored the highest, CA9, CLDN18, TNC, MMP9, and EGFR, and they were evaluated in detail. None of these biomarkers had high sensitivity or specificity for CCA but have potential for theranosis. This review is unique in that it describes the process of selecting suitable markers for theranosis, which is also applicable to other diseases. This has highlighted existing validated markers of CCA that can be used for active tumor targeting for the future development of targeted t...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research