GSE153646 Fibroblasts direct differentiation of human breast epithelial progenitors

Conclusions: The significance of the most prominent cell type in normal breast stroma, the fibroblast, in directingepithelial differentiation is largely unknown. Through establishment of lobular and interlobular fibroblast cell lines,we here demonstrate that epithelial progenitors are submitted to stromal cues for site-specific differentiation. Ourfindings lend credence to considering stromal subtleties of crucial importance in the development of normal breastand, in turn, breast cancer.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by high throughput sequencing Homo sapiens Source Type: research