Suboptimal SARS-CoV-2-specific CD8+ T cell response associated with the prominent HLA-A*02:01 phenotype [Immunology and Inflammation]
An improved understanding of human T cell-mediated immunity in COVID-19 is important for optimizing therapeutic and vaccine strategies. Experience with influenza shows that infection primes CD8+ T cell memory to peptides presented by common HLA types like HLA-A2, which enhances recovery and diminishes clinical severity upon reinfection. Stimulating peripheral blood...
Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Jennifer R. Habel, Thi H. O. Nguyen, Carolien E. van de Sandt, Jennifer A. Juno, Priyanka Chaurasia, Kathleen Wragg, Marios Koutsakos, Luca Hensen, Xiaoxiao Jia, Brendon Chua, Wuji Zhang, Hyon-Xhi Tan, Katie L. Flanagan, Denise L. Doolan, Joseph Torresi, Tags: Coronavirus (COVID-19) Biological Sciences Source Type: research
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