Molecular and genetic characterization of natural variants of HIV-1 Nef gene from North India and its functional implication in down-regulation of MHC-I and CD-4.

CONCLUSION: We observed enhanced biological activities in some of the variants, perhaps arising out of amino acid substitutions in their functional domains. The CD4 and MHC-1 down-regulation activity of Nef is likely to confer immense survival advantage allowing the most rare genotype in a population to become the most abundant after a single selection event. PMID: 32981506 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32981506?dopt=Abstract

Source: Current HIV Research - September 24, 2020 Category: Infectious Diseases Authors: Singh J, Ronsard L, Pandey M, Kapoor R, Ramachandran VG, Banerjea AC Tags: Curr HIV Res Source Type: research