Long term follow-up of high dose chemotherapy with autologous stem cell transplantation in children and young adults with metastatic or relapsed Ewing's sarcoma – a single-institution experience
Ewing Sarcoma (EWS) arises in bone and soft tissue and most commonly occurs in adolescents and young adults. With current therapy, the survival rate ranges from 75 –80% for pts with localized disease at diagnosis.1, 2 Unfortunately, pts with metastatic disease at diagnosis have a much poorer outcome when treated with standard chemotherapy with a 3-year survival rate range between 10-30%.1-3 Further, the survival rate for pts with recurrent disease also remai ns poor despite aggressive treatment; 5-year OS for pts with recurrent or progressive disease after first-line therapy ranges between 0 to 20%.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Anna B. Pawlowska, Victoria Sun, George T. Calvert, Nicole A. Karras, Judith K. Sato, Clarke P. Anderson, Jerry C. Cheng, Julie F. DiMundo, Joseph D. Femino, J'Rick Lu, Dongyun Yang, Andrew Dagis, James S. Miser, Joseph Rosenthal Source Type: research
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