Long term follow-up of high dose chemotherapy with autologous stem cell transplantation in children and young adults with metastatic or relapsed Ewing's sarcoma – a single-institution experience

Ewing Sarcoma (EWS) arises in bone and soft tissue and most commonly occurs in adolescents and young adults. With current therapy, the survival rate ranges from 75 –80% for pts with localized disease at diagnosis.1, 2 Unfortunately, pts with metastatic disease at diagnosis have a much poorer outcome when treated with standard chemotherapy with a 3-year survival rate range between 10-30%.1-3 Further, the survival rate for pts with recurrent disease also remai ns poor despite aggressive treatment; 5-year OS for pts with recurrent or progressive disease after first-line therapy ranges between 0 to 20%.
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research