Cancers, Vol. 12, Pages 2796: The Association of Residential Altitude on the Molecular Profile and Survival of Melanoma: Results of an Interreg Study

Cancers, Vol. 12, Pages 2796: The Association of Residential Altitude on the Molecular Profile and Survival of Melanoma: Results of an Interreg Study Cancers doi: 10.3390/cancers12102796 Authors: Eleonora De Martino Davide Brunetti Vincenzo Canzonieri Claudio Conforti Klaus Eisendle Guido Mazzoleni Carla Nobile Federica Rao Johannes Zschocke Emina Jukic Wolfram Jaschke Georg Weinlich Bernhard Zelger Matthias Schmuth Giorgio Stanta Fabrizio Zanconati Iris Zalaudek Serena Bonin Cutaneous melanoma (CM) incidence is rising worldwide and is the primary cause of death from skin disease in the Western world. Personal risk factors linked to environmental ultraviolet radiation (UVR) are well-known etiological factors contributing to its development. Nevertheless, UVR can contribute to the development of CM in different patterns and to varying degrees. The present study aimed at investigating whether altitude of residence can contribute to the development of specific types of CM and/or influence its progression. To this aim, 306 formalin-fixed and paraffin-embedded (FFPE) tissues from primary CM diagnosed in different geographical areas were submitted to B-RAF proto-oncogene serine/threonine kinase (BRAF) and N-RAS proto-oncogene GTPase (NRAS) mutational status detection and mRNA and miRNA profiling by qPCR. Genes were chosen for their functions in specific processes, such as immune response (CD2, PDL1, or CD274) and pigmentation (MITF, TYRP1, ...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research