Slower degradation rate of cytarabine in blood samples from acute myeloid leukemia by comparison with control samples

ConclusionCytarabine stability is higher in AML than in CTRL samples. The absence of correlation betweent1/2IVdeg and AUCIVlast in AML samples suggests that in vitro cytarabine degradation in AML is complex. These results open perspectives including the evaluation of the clinical relevance and the involved molecular mechanisms.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research