LGR4 maintains HGSOC cell epithelial phenotype and stem-like traits.

CONCLUSION: Together, these data demonstrate that WNT7B/FZD5-LGR4/ELF3 axis maintains HGSOC cell epithelial phenotype and stem-like traits; targeting this axis may prevent HGSOC metastasis.
PMID: 32980127 [PubMed - as supplied by publisher]

Source: Gynecologic Oncology - September 23, 2020 Category: Cancer & Oncology Authors: Wang Z, Yin P, Sun Y, Na L, Gao J, Wang W, Zhao C Tags: Gynecol Oncol Source Type: research