AbbVie Receives Orphan Drug and Fast Track Designations from the U.S. Food and Drug Administration for Elezanumab, an Investigational Monoclonal Antibody RGMa Inhibitor, for the Treatment of Spinal Cord Injury

Elezanumab (ABT-555) is an investigational treatment being evaluated in neurological disorders, including treatment following spinal cord injury Orphan Drug Designation is given to a drug or biologic for the treatment, diagnosis or prevention of a rare ... Biopharmaceuticals, Neurology, FDA AbbVie, elezanumab, spinal cord injury
Source: HSMN NewsFeed - Category: Pharmaceuticals Source Type: news

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Study Design. Retrospective study. Objective. We identified radiological risk factors for neurological deficits in mid and low lumbar spinal fractures. Summary of Background Data. Although numerous studies have focused on radiological risk factors for neurological deficits in spinal cord injury or thoracolumbar junction area fractures, few have examined mid and low lumbar fractures at the cauda equina level. Methods. We retrospectively reviewed 71 consecutive patients who suffered acute traumatic mid and low lumbar fractures (L2–L5) corresponding to the cauda equina level, as confirmed on magnetic resonanc...
Source: Spine - Category: Orthopaedics Tags: DIAGNOSTICS Source Type: research
Publication date: Available online 8 October 2020Source: Brain, Behavior, and ImmunityAuthor(s): Yun Li, Rodney M Ritzel, Junyun He, Tuoxin Cao, Boris Sabirzhanov, Hui Li, Simon Liu, Long-Jun Wu, Junfang Wu
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
AbstractRheumatoid arthritis (RA) is a progressive autoimmune inflammatory disease affecting 1% of the population with three times as many women as men. As many as 86% of patients suffering from RA have cervical spine involvement. Synovial inflammation in the cervical spine causes instability and injuries including atlantoaxial subluxation, retroodontoid pannus formation, cranial settling, and subaxial subluxation. While many patients with cervical spine involvement are asymptomatic, symptomatic patients often present with nonspecific symptoms resulting from inflammation and additional secondary symptoms that are due to co...
Source: Neurosurgical Review - Category: Neurosurgery Source Type: research
Publication date: Available online 9 October 2020Source: NeuroscienceAuthor(s): Xinwei Liu, Bin Ma, Haocong Zhang, Ruonan Chai, Liangbi Xiang
Source: Neuroscience - Category: Neuroscience Source Type: research
Conclusion: A preganglionic cervical nerve root avulsion should not be a contraindication for a stellate ganglion block in a patient with established CRPS. PMID: 33024600 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Publication date: Available online 7 October 2020Source: Journal of Chemical NeuroanatomyAuthor(s): Reza Salarinia, Mahmoud Hosseini, Yousef Mohamadi, Ahmad Ghorbani, Daryoush Hamidi Alamdari, Asghar Mafinezhad, Hamidreza Sadeghnia
Source: Journal of Chemical Neuroanatomy - Category: Neuroscience Source Type: research
Discussion: The results of this study may help to establish CEUS as a suitable imaging modality for the evaluation of potentially vasodilatory drugs in the field of sports. Other supplements could also be evaluated in this way to verify the content of their advertising claims. Trial registration: German Clinical Trials Register (DRKS), ID: DRKS00016972, registered on 25.03.2019.
Source: Medicine - Category: Internal Medicine Tags: Research Article: Study Protocol Clinical Trial Source Type: research
Spinal cord injury (SCI) favors a persistent pro-inflammatory macrophages/microglia-mediated response with only a transient appearance of anti-inflammatory phenotype of immune cells. However, the mechanisms co...
Source: Journal of Neuroinflammation - Category: Neurology Authors: Tags: Research Source Type: research
This study examined longitudinal changes in post-traumatic stress symptoms (PTSS) in individuals newly diagnosed with spinal cord injury (SCI) and tested various psychosocial and injury-related characteristics as predictors for interindividual d...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
CONCLUSION: Partial bladder recovery has been evident after SC therapy in SCI models. Due to limitations in the number of studies in other neurological diseases, additional studies are necessary to confirm the detailed mechanism for bladder recovery. PMID: 33017895 [PubMed]
Source: International Neurourology Journal - Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research
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