Congenital myopathies 1 – nemaline

Ovine congenital progressive muscular dystrophy (OCPMD) was first described in Merino sheep flocks in Queensland and Western Australia (WA) in the 1960s and 70s. The most prominent feature of the disease is a distinctive gait with stiffness of the hind limbs that can be seen as early as three weeks after birth. The disease is progressive. Histopathological examination had revealed dystrophic changes specifically in slow myofibres, while electron microscopy had demonstrated abundant nemaline bodies.

Source: Neuromuscular Disorders - September 28, 2020 Category: Neurology Authors: J. Clayton, E. McNamara, H. Goullee, S. Conijn, K. Muthsam, G. Musk, D. Coote, J. Kijas, A. Testa, R. Taylor, M. O'Hara, D. Groth, C. Ottenheijm, G. Ravenscroft, N. Laing, K. Nowak Source Type: research