Muscle function & homeostasis / molecular therapeutic approaches

Satellite cells are residential muscle stem cells that express a paired box transcription factor PAX7. Pax7 has been shown to be involved in determination of myogenic cell lineage during development, yet it is also required for the postnatal muscle growth, muscle regeneration and maintenance of the satellite cell pool. Although the functions of Pax7 have been studied thoroughly, its interacting partners in myogenic cells in vivo are largely unknown due to the lack of proper antibodies for immunoprecipitation.

Source: Neuromuscular Disorders - September 28, 2020 Category: Neurology Authors: S. Hayashi, Y. Inoue, H. Kosako, T. Inoue, S. Noguchi, I. Nishino Source Type: research