Limb girdle muscular dystrophies
Patients with autosomal recessive LGMD subtype 2 (LGMD2) may experience severe mobility impairments (including loss of ambulation [LOA]). As clinical heterogeneity exists among patients with LGMD, the objective was to synthesize data on the timing of LOA among patients with LGMD2, particularly calpainopathy (LGMD2A), dysferlinopathy (LGMD2B/Miyoshi myopathy [MM]), and sarcoglycanopathies (LGMD2C-F). In this systematic review, a study-specific search strategy was implemented in MEDLINE and EMBASE in September 2019.
Source: Neuromuscular Disorders - Category: Neurology Authors: A. Cheung, I. Audhya, S. Szabo, M. Harwood, K. Gooch Source Type: research