Muscle imaging – mri

The degree of muscle replacement by fat, as determined from fat fraction (FF) maps using quantitative nuclear magnetic resonance imaging (NMRI), is a marker of ‘disease progression’ and has an integrative character. More predictive NMR biomarkers, reflecting rather the ‘disease activity’, such as water T2 and phosphorus (31P) NMR spectroscopy indices have proven their value in different neuromuscular disorders. Here, we investigated the correlation between the FF and FF changes over three years (ΔFF) and different 31P NMRS indices, including the level of phosphodiesters (PDE), normalized over the signal of adenosine triphosphate, ATP, (reflecting membrane phospholipid turnover), the ratio of inorganic phosphate, Pi, to phosphocreatine, PCr, (a marker of mitochondrial function), the ratio of PCr to ATP (reflecting the metabolically active muscle), and pH.

Source: Neuromuscular Disorders - September 28, 2020 Category: Neurology Authors: H. Reyngoudt, F. Smith, E. Caldas de Almeida Araujo, I. Wilson, R. Fernandez Torron, M. James, U. Moore, B. Marty, L. Rufibach, H. Heather, H. Sutherland, J. Hogrel, T. Stojkovic, K. Bushby, V. Straub, P. Carlier, A. Blamire, Jain Foundation COS consortiu Source Type: research