Dmd – animal models & preclinical treatment

Duchenne muscular dystrophy (DMD) is an X-linked neuromuscular disorder caused by the absence of dystrophin protein. Upon exhaustion of the regenerative capacity of muscle, there is an imbalance between muscle damage and repair. Insulin-like growth factor 1 (IGF-1) plays an essential role in increasing muscle mass and strength, reducing degeneration, inhibiting chronic inflammation and increasing the proliferation potential of satellite cells. Although liver is the main source of IGF-1, it is also expressed in different tissues including skeletal muscle.

Source: Neuromuscular Disorders - September 28, 2020 Category: Neurology Authors: A. Yavas, M. van Putten, E. Niks, A. Aartsma-Rus Source Type: research