Highlights across myology

Gene editing in cells has revolutionized the paradigm of modern cell biology. The ease of use of the CRISPR/Cas9 system for gene manipulation has led to rapid and wide adoption across many fields, including biological research, biotechnology and medicine. This technology allows gene modification by producing a specific double stranded cut in the DNA and the repair by homology-independent targeted insertion (HITI) of DNA. We used CRISPR/CAS9 to modify specific mutations in-vitro in a muscular disorder to show its potential use as a therapeutic tool.

Source: Neuromuscular Disorders - September 28, 2020 Category: Neurology Authors: N. Sabha, H. Gonorazky, S. Khattak, S. Viththiyapaskaran, N. Bhambra, H. Granzier, J. Dowling Source Type: research