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Efficient cell migration requires cellular polarization, which is characterized by the formation of leading and trailing edges, appropriate positioning of the nucleus and reorientation of the Golgi apparatus and centrosomes towards the leading edge. Migration also requires the development of an asymmetrical front-to-rear calcium gradient to regulate focal adhesion assembly and actomyosin contractility. Here we demonstrate that silencing of syndecan-4, a transmembrane heparan sulfate proteoglycan, interferes with the correct polarization of migrating mammalian myoblasts (i.e., activated satellite stem cells).

Source: Neuromuscular Disorders - September 28, 2020 Category: Neurology Authors: Daniel Becsky, Kitti Szabo, Szuzina Gyulai-Nagy, Tamas Gajdos, Zsuzsa Bartos, Arpad Balind, Prof. Dr. Laszlo Dux, Dr. Peter Horvath, Dr. Miklos Erdelyi, Dr. Laszlo Homolya, Dr. Aniko Keller-Pinter Source Type: research