Ossabaw Pig Demonstrates Detrusor Fibrosis and Detrusor Underactivity Associated with Oxidative Stress in Metabolic Syndrome.

In conclusion, the Ossabaw pig model for diet-induced MetS is associated with oxidative stress and profibrotic activity in the bladder, which results in DU. This has previously been shown in mice and rats, but never in pigs. This novel model will better represent human MetS and DBD because the mechanism and size of the pig bladder more closely resemble that of a human, resulting in a more valid model and facilitating further study into the signaling mechanisms responsible for this impairment.
PMID: 32972487 [PubMed - as supplied by publisher]

Source: Comparative Medicine - September 23, 2020 Category: Zoology Authors: Powell CR, Kim A, Roth J, Byrd JP, Mohammad K, Alloosh M, Vittal R, Sturek M Tags: Comp Med Source Type: research