Antiviral effect of Hornstedtia bella Škorničk essential oil from the whole plant against vaccinia virus (VV).

Antiviral effect of Hornstedtia bella Škorničk essential oil from the whole plant against vaccinia virus (VV). Nat Prod Res. 2020 Sep 25;:1-7 Authors: Sanna G, Madeddu S, Serreli G, Nguyen HT, Le NT, Usai D, Carta A, Cappuccinelli P, Zanetti S, Donadu MG Abstract In the prevention of epidemic and pandemic emerging and neglected viral infections, natural products are an important source of lead compounds. Hornstedtia bella Škorničkis is a rhizomatous herb growing in the forest of central Vietnam. Hornstedtia bella essential oil (Hb EO) was recently characterised by our group as endowed of antimicrobial activity against Staphylococcus aureus Methicillin-Resistant strains. Here, we describe for the first time the evaluation of Hb EO against a spectrum of viruses responsible for important human diseases. Hb EO resulted active against Vaccinia virus (VV) (EC50 values 80 μg/mL), closely related to variola virus, causative agent of smallpox. Hb EO was able to strongly reduce the viral VV titer in cell-based assay at not cytotoxic concentration and its potential mode of action was characterised by virucidal activity evaluation followed by time-of-addition assay. Furthermore, Hb EO antiviral activity was implemented in a combination study with the mycophenolic acid. PMID: 32975126 [PubMed - as supplied by publisher]
Source: Natural Product Research - Category: Biochemistry Authors: Tags: Nat Prod Res Source Type: research

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