Type 2 diabetes and aortic aneurysms: protective role of macrophages metabolism

Patients presenting type 2 diabetes appear paradoxically protected from the appearance and the evolution of an abdominal aortic aneurysm (AAA). Immune cells take an active part in the weakening of the aortic wall of AAAs, with an important role of the macrophages. Their pro or anti-inflammatory phenotype is partly determined by the cellular metabolism. We hypothesized that diabetes could influence the metabolic phenotype of the macrophages, and thus explain the protective role of diabetes in AAAs.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Source Type: research

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The Usher Institute at the University of Edinburgh is seeking a highly skilled and motivated epidemiologist/research fellow to work in the field of vascular disease, including both the diagnosis and treatment of peripheral vascular diseases and the development of vascular complications of type 2 diabetes. The primary role will be to undertake a series of high quality systematic reviews on the prevention, diagnosis and treatment of vascular diseases, including abdominal aortic aneurysm, venous thromboembolism and peripheral arterial disease, within the core programme of work which constitutes the CSO funded research project...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
CONCLUSIONS: Pharmacological inhibition of SGLT-2 by empagliflozin inhibits AAA formation. SGLT-2 inhibition might represent a novel promising therapeutic strategy to prevent AAA progression ( Visual Overview ). PMID: 31294626 [PubMed - as supplied by publisher]
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research
Epidemiologic data indicate decreased risk for development, growth, and rupture of abdominal aortic aneurysm (AAA) among patients with type 2 diabetes mellitus (DM). We therefore evaluated mortality and cardiovascular morbidity after acute repair of AAA in diabetic and nondiabetic patients.
Source: Journal of Vascular Surgery - Category: Surgery Authors: Source Type: research
Epidemiological data indicate decreased risk for development and growth of abdominal aortic aneurysm (AAA) among patients with diabetes mellitus (DM), but DM also goes with increased cardiovascular (CV) morbidity and mortality. We evaluated effects of DM on mortality and CV morbidity after elective open AAA repair.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Clinical Research, Basic Science Source Type: research
Epidemiological data indicate decreased risk for development and growth of abdominal aortic aneurysm (AAA) among patients with diabetes mellitus (DM), but DM also goes with increased cardiovascular (CV) morbidity and mortality. We evaluated the effects of DM on mortality and CV morbidity after elective open AAA repair.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Clinical Research Source Type: research
The objective of this study was to study the link between insulin-resistance and the size of AAAs.
Source: Annals of Vascular Surgery - Category: Surgery Authors: Tags: Abstracts Presented to the French Society for Vascular and Endovascular Surgery Source Type: research
Abstract Leptin, an adipokine that is implicated in the control of food intake via appetite suppression, may also stimulate oxidative stress, inflammation, thrombosis, arterial stiffness, angiogenesis and atherogenesis. These leptin-induced effects may predispose to the development of cardiovascular diseases. In the present review we discuss the evidence linking leptin levels with the presence, severity and/or prognosis of both coronary artery disease and non-cardiac vascular diseases such as stroke, carotid artery disease, peripheral artery disease (PAD) and abdominal aortic aneurysms (AAA) as well as with chroni...
Source: Acta Pharmacologica Sinica - Category: Drugs & Pharmacology Authors: Tags: Acta Pharmacol Sin Source Type: research
We examined the associations of T1DM and T2DM with incidence of seven CVD outcomes.
Source: International Journal of Cardiology - Category: Cardiology Authors: Source Type: research
I hear this comment with some regularity when, for instance, someone recognizes me as the author of the Wheat Belly series. This is a step in the right direction. But saying that you have a wheat intolerance is like saying “I have a tobacco intolerance.” The impact of tobacco smoking on health ranges from mild impairment, to incapacitating diseases such as chronic lung disease and abdominal aortic aneurysms, to death. A rare person escapes the ravages of years of smoking, but most people develop at least one, if not half-a-dozen, health problems from cigarettes. And so it goes with wheat: It’s a rare pers...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: Wheat Belly Lifestyle gluten gluten-free grain grain-free grains health Inflammation Source Type: blogs
Purpose of review: Adiponectin is an adipokine with anti-inflammatory, antioxidant, antiatherogenic, pro-angiogenic, vasoprotective and insulin-sensitizing properties. Several factors may influence adiponectin levels, such as genetic polymorphisms, obesity / body fat distribution, diet and exercise as well as cardiovascular risk factors such as sleep deprivation and smoking as well as medications. Adiponectin has been proposed as a potential prognostic biomarker and a therapeutic target in patients with cardiometabolic diseases. Recent findings: This narrative review discusses the associations of adiponectin with obesity-...
Source: Current Opinion in Lipidology - Category: Lipidology Tags: HYPERLIPIDAEMIA AND CARDIOVASCULAR DISEASE: Edited by Paul N. Durrington Source Type: research
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