Type 2 diabetes and aortic aneurysms: protective role of macrophages metabolism

Patients presenting type 2 diabetes appear paradoxically protected from the appearance and the evolution of an abdominal aortic aneurysm (AAA). Immune cells take an active part in the weakening of the aortic wall of AAAs, with an important role of the macrophages. Their pro or anti-inflammatory phenotype is partly determined by the cellular metabolism. We hypothesized that diabetes could influence the metabolic phenotype of the macrophages, and thus explain the protective role of diabetes in AAAs.

Source: Annals of Vascular Surgery - September 27, 2020 Category: Surgery Authors: Joseph Carboni, Nirvana Sadaghianloo, Brigitte Sibille, Claudine Moratal, Fabien Lareyre, R éda Hassen-Khodja, Elixène Jean-Baptiste, Juliette Raffort, Jaap Neels, Giulia Chinetti Source Type: research