The use of M2-pyruvate kinase as a stool biomarker for detection of colorectal cancer in tertiary teaching hospital: A comparative study.

Conclusion: Faecal M2-PK Quick test has a high sensitivity for detection of colorectal cancer when compared to gFOBT, making it the potential choice for colorectal tumour screening biomarker in the future. PMID: 32972105 [PubMed - as supplied by publisher]
Source: Annals of Coloproctology - Category: Gastroenterology Tags: Ann Coloproctol Source Type: research

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Conclusions Using a relatively small set of publicly-available colonoscopy data, we obtained sizable training and validation sets of endoscopic images using data augmentation, and achieved an excellent performance in adenomatous polyp detection. [...] Georg Thieme Verlag KG Rüdigerstraße 14, 70469 Stuttgart, GermanyArticle in Thieme eJournals: Table of contents  |  Abstract  |  open access Full text
Source: Endoscopy International Open - Category: Gastroenterology Authors: Tags: Original article Source Type: research
Endosc Int Open 2020; 08: E1495-E1501 DOI: 10.1055/a-1242-9958 Background and study aims Patients with cirrhosis demonstrate alterations in physiology, hemodynamics, and immunity which may increase procedural risk. There exist sparse data regarding the safety of performing ambulatory colonoscopy in patients with cirrhosis. Patients and methods From a population-based sample of three North American states (California, Florida, and New York), we collected data on 3,590 patients with cirrhosis who underwent ambulatory colonoscopy from 2009 to 2014. We created a control cohort propensity score-matched for ci...
Source: Endoscopy International Open - Category: Gastroenterology Authors: Tags: Original article Source Type: research
ConclusionsOur study showed moderate interobserver agreement about the histopathological detection and classification of IBD-associated dysplasia. Further efforts should be undertaken to integrate the histopathological data with both the ancillary tests and molecular investigations.
Source: Techniques in Coloproctology - Category: Surgery Source Type: research
The aim of this study was to investigate the relationship between textbook outcome and survival in patients with surgically treated colon cancer. A total of 804 surgical cases were enrolled between June 1, 2010 and December 31, 2014. Textbook outcome was defined as patients who had colon cancer surgery and met the six healthcare parameters of surgery within 6 weeks, radical resection, lymph node (LN) yield ≥12, no ostomy, no adverse outcome and colonoscopy before/after surgery within 6 months. The effect of textbook outcome on 5-year disease-specific survival (DSS) was calculated using the Kaplan-Meier method. A Cox reg...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
Fluorescence molecular endoscopy (FME) is an emerging technique that has the potential to improve the 22% colorectal polyp detection miss-rate. We determined the optimal dose-to-imaging interval and safety of FME using EMI-137, a c-Met–targeted fluorescent peptide, in a population at high risk for colorectal cancer. Methods: We performed in vivo FME and quantification of fluorescence by multidiameter single-fiber reflectance/single-fiber fluorescence spectroscopy in 15 patients with a dysplastic colorectal adenoma. EMI-137 was intravenously administered (0.13 mg/kg) at a 1-, 2- or 3-h dose-to-imaging interval (n = 3 ...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Clinical Source Type: research
This study assessed the effects of Medicaid expansion on elective CRS rates by race/ethnicity.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Health services research Source Type: research
Colonoscopy is the most commonly performed endoscopic examination worldwide and is considered the gold standard for colorectal cancer screening.The quality of examination and endoscopic treatment is affected by a number of factors that are verified by recognized parameters, such as cecal intubation rate and time, withdrawal time, adenoma detection rate and polyp detection rate.The aim of the study was to assess the suitability of 330-degree panoramic colonoscopy for the detection of colorectal lesions and to analyze the functionality of a special endoscope series in regard to cecal intubation rate, cecal intubation time, and withdrawal time.
Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Colon and rectal surgery Source Type: research
CONCLUSION: A large proportion of IBD patients experienced colonoscopy as moderate to severely uncomfortable but would still accept colonoscopy surveillance frequency according to current guidance. Participants expected sensitivities ≥95% for potential alternatives to colonoscopy based surveillance programs. PMID: 32981385 [PubMed - as supplied by publisher]
Source: Expert Review of Gastroenterology and Hepatology - Category: Gastroenterology Tags: Expert Rev Gastroenterol Hepatol Source Type: research
Colonoscopy is required following a positive fecal screening test for colorectal cancer (CRC). It remains unclear to what extent time to colonoscopy is associated with CRC-related outcomes. We performed a systematic review to elucidate this relationship.
Source: Clinical Gastroenterology and Hepatology - Category: Gastroenterology Authors: Source Type: research
CONCLUSION: This study provides additional evidence of the association between low fruit and vegetable consumption and colorectal polyps. Enhancing people fiber eating behavior may help preventing colorectal cancer risk. PMID: 32986375 [PubMed - as supplied by publisher]
Source: Asian Pacific Journal of Cancer Prevention - Category: Cancer & Oncology Tags: Asian Pac J Cancer Prev Source Type: research
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