miR-100 inhibits cell proliferation in mantle cell lymphoma by targeting mTOR

ConclusionsAbnormal expression of miR-100 and mTOR was found in MCL, which included downregulation of miR-100 and upregulation of mTOR. The expression of mTOR is negatively correlated with miR-100. It may play an important role in MCL pathogenesis. miR-100 up-regulation can inhibit cell proliferation, promote cell apoptosis, and inhibit cell cycle in G1 phase by targeting the mTOR gene. miR-100 may potentially be an anti-mantle cell lymphoma gene.

http://link.springer.com/10.1186/s40164-020-00182-2

Source: Experimental Hematology and Oncology - September 25, 2020 Category: Cancer & Oncology Source Type: research