Short stature is associated with higher pulse wave velocity in subjects without overt cardiovascular disease

Short stature is reportedly associated with cardiovascular disease (CVD). However, the mechanism underlying this intriguing epidemiological finding is unclear. Pulse wave velocity (PWV), a marker of vascular stiffness, is a predictor of future CVD. Therefore, PWV may be affected by height even before overt CVD occurs. Here, we investigated the association between adult height and PWV in subjects without overt CVD. A total of 1019 subjects (48ā€ŠĀ±ā€Š12 years old; 509 men, 21 with diabetes mellitus, 209 with hypertension) without overt CVD were enrolled, all of whom underwent brachial-ankle PWV (baPWV) measurements. The subjects were divided into 3 groups by height. A multiple regression model was used to estimate baPWV values among heights after the adjustment for confounders. Mean baPWV value was highest in the group with the shortest height for both sexes (both Pā€Š
Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research