Pain relief for osteoarthritis through combined treatment (PROACT): Protocol for a randomized controlled trial of mindfulness meditation combined with transcranial direct current stimulation in non-Hispanic black and white adults with knee osteoarthritis

Knee osteoarthritis (OA) is a leading cause of late life pain and disability, and non-Hispanic black (NHB) adults experience greater OA-related pain and disability than non-Hispanic whites (NHWs). Recent evidence implicates psychosocial stress, cognitive-attentional processes, and altered central pain processing as contributors to greater OA-related pain and disability among NHBs. To address these ethnic/race disparities, this clinical trial will test whether a mindfulness intervention (Breathing and Attention Training, BAT) combined with transcranial direct current stimulation (tDCS) will enhance pain modulatory balance and pain-related brain function, reduce clinical pain, and attenuate ethnic differences therein, among NHBs and NHWs with knee OA.

Source: Contemporary Clinical Trials - September 24, 2020 Category: Radiology Authors: Roger B. Fillingim, Adam J. Woods, Hyochol Ahn, Samuel S. Wu, David T. Redden, Song Lai, Hrishikesh Deshpande, Georg Deutsch, Kimberly T. Sibille, Roland Staud, Fadel Zeidan, Burel R. Goodin Source Type: research