COVID-19 associated with pulmonary aspergillosis: A literature review
Publication date: Available online 24 September 2020Source: Journal of Microbiology, Immunology and InfectionAuthor(s): Chih-Cheng Lai, Weng-Liang Yu
The coronavirus disease 2019 (COVID-19) virus caused a wide spectrum of disease in healthy individuals, as well as those with common comorbidities . Severe COVID-19 is characterised by acute respiratory distress syndrome (ARDS) secondary to viral pneumonitis, treatment of which may require mechanical ventilation or extracorporeal membrane oxygenation . Clinicians are alert to the possibility of bacterial co-infection as a complication of lower respiratory tract viral infection; for example, a recent review found that 72% of patients with COVID-19 received antimicrobial therapy . However, the risk of fungal co-infe...
Abstract Bacterial or virus co-infections with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) have been reported in many studies, however, the knowledge on Aspergillus co-infection among patients with coronavirus disease 2019 (COVID-19) was limited. This literature review aims to explore and describe the updated information about COVID-19 associated with pulmonary aspergillosis. We found that Aspergillus spp. can cause co-infections in patients with COVID-19, especially in severe/critical illness. The incidence of IPA in COVID-19 ranged from 19.6% to 33.3%. Acute respiratory distress syndrome requiri...
Publication date: Available online 22 August 2020Source: IDCasesAuthor(s): Shiema Abdalla, Muna A. Almaslamani, Samar M. Hashim, Abdulsalam S. Ibrahim, Ali S. Omrani
More than a quarter of intubated patients with COVID-19 have evidence of invasive pulmonary aspergillosis, according to a new study.Reuters Health Information
Purpose of review Although clinical outcomes in the treatment of aspergillosis have markedly improved with the availability of newer triazoles, the development of resistance to these antifungals, especially in Aspergillus fumigatus, is a growing concern. The purpose of this review is to provide an update on azole resistance mechanisms and their epidemiology in A. fumigatus, the clinical implications of azole resistance, and to discuss future treatment options against azole-resistant aspergillosis. Recent findings Resistance may develop through either patient or environmental azole exposure. Environmental exposure is t...
PMID: 32687390 [PubMed - as supplied by publisher]
PMID: 32687389 [PubMed - as supplied by publisher]
PMID: 32668167 [PubMed - as supplied by publisher]
Publication date: Available online 8 July 2020Source: Journal of Critical CareAuthor(s): Antine W. Flikweert, Marco J.J.H. Grootenboers, David C.Y. Yick, Arthur W.F. du Mée, Nardo J.M. van der Meer, Thijs C.D. Rettig, Merijn K.M. Kant