The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases.

The role of reactive oxygen species in the pathogenesis and treatment of retinal diseases.
Exp Eye Res. 2020 Sep 21;:108255
Authors: Chan TC, Wilkinson Berka JL, Deliyanti D, Hunter D, Fung A, Liew G, White A
Abstract
Reactive oxygen species (ROS) normally play an important physiological role in health regulating cellular processes and signal transduction. The amount of ROS is usually kept in fine balance with the generation of ROS largely being offset by the body's antioxidants. A tipping of this balance has increasingly been recognised as a contributor to human disease. The retina, as a result of its cellular anatomy and physical location, is a potent generator of ROS that has been linked to several major retinal diseases. This review will provide a summary of the role of oxidative stress in the pathogenesis of diabetic retinopathy, age-related macular degeneration, myopia, retinal vein occlusion, retinitis pigmentosa and retinopathy of prematurity. Therapies aimed at controlling oxidative stress in these diseases are also examined.
PMID: 32971094 [PubMed - as supplied by publisher]

Source: Experimental Eye Research - September 20, 2020 Category: Opthalmology Authors: Chan TC, Wilkinson Berka JL, Deliyanti D, Hunter D, Fung A, Liew G, White A Tags: Exp Eye Res Source Type: research