Characteristics and prognostic significance of genetic mutations in acute myeloid leukemia based on a targeted next ‐generation sequencing technique

Genetic mutations can predict favorable or unfavorable prognosis of AML patients. Allo stem cell transplantation can provide benefits for AML patients with bad genetic mutations. AbstractTo explore the characteristics and prognostic significance of genetic mutations in acute myeloid leukemia (AML), we screened the gene mutation profile of 171 previously untreated AML patients using a next ‐generation sequencing technique targeting 127 genes with potential prognostic significance. A total of 390 genetic alterations were identified in 149 patients with a frequency of 87.1%. Younger age and high sensitivity to induction chemotherapy were associated with a lower number of mutations.NPM1 mutation was closely related toDNMT3A andFLT3‐internal tandem duplication (FLT3‐ITD) mutations, but mutually exclusive withASXL1 mutation andCEBPAdouble mutation. In univariate analysis,ASXL1 orTET2 mutation predicted shorter overall survival (OS) or relapse ‐free survival (RFS),DNMT3A,FLT3‐ITD, orRUNX1 mutation predicted a higher likelihood of remission ‐induction failure, whereasNRAS mutation orCEBPAdouble mutation predicted longer OS. ConcurrentDNMT3A,FLT3 ‐ITD, andNPM1 mutations predicted shorter OS. Hypomethylation agents could improve the OS in patients with DNA methylation ‐related mutations. According to multivariate analysis,TET2 mutation was recognized as an independent prognostic factors for RFS. In summary, our study provided a detailed pattern of gene mutations and the...
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research

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