Bronchospasmolytic and Adenosine Binding Activity of 8- (Proline / Pyrazole)-Substituted Xanthine Derivatives.

CONCLUSION: Newly synthesized proline/pyrazole based xanthines compounds showed a satisfactory binding affinity for adenosine receptor subtypes. Replacement or variation of substituted proline ring with substituted pyrazole scaffold at 8thposition of xanthine moiety resulted in the reduction of adenosine binding affinity and bronchospasmolytic effects. PMID: 32962622 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/32962622?dopt=Abstract

Source: Current Drug Discovery Technologies - September 21, 2020 Category: Drugs & Pharmacology Authors: Singh S, Ojha M, Yadav D, Kachler S, Klotz KN, Yadav R Tags: Curr Drug Discov Technol Source Type: research