The TGFB1 -509C/T polymorphism and elevated TGF- β1 levels are associated with chronic hepatitis C and cirrhosis.

In conclusion, the TGFB1 -509C > T polymorphism is associated with a risk of developing chronic hepatitis C, leading to increased TGF-β1, which inhibits IFN-γ production, contributing to the progression to cirrhosis. PMID: 32962821 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/32962821?dopt=Abstract

Source: Immunobiology - August 31, 2020 Category: Allergy & Immunology Authors: de Brito WB, Queiroz MAF, da Silva Graça Amoras E, Lima SS, da Silva Conde SRS, Dos Santos EJM, Cayres-Vallinoto IMV, Ishak R, Vallinoto ACR Tags: Immunobiology Source Type: research