Donor-specific antibody characteristics, including persistence and complement-binding capacity, increase risk for chronic lung allograft dysfunction

Chronic lung allograft dysfunction (CLAD) is the major complication limiting long-term survival in lung transplant recipients (LTRs), with those developing donor-specific anti –human leukocyte antigen (HLA) antibodies (DSAs) previously found to have increased risk for CLAD. However, as DSA responses vary in timing of development, specificity, breadth, persistence, and complement-binding capacity, we hypothesized that these characteristics would impact CLAD and survival outcomes.

Source: The Journal of Heart and Lung Transplantation - September 8, 2020 Category: Transplant Surgery Authors: Carlo J. Iasella, Christopher R. Ensor, Marilyn Marrari, Massimo Mangiola, Qingyong Xu, Eric Nolley, Cody A. Moore, Matthew R. Morrell, Joseph M. Pilewski, Pablo G. Sanchez, John F. McDyer, Adriana Zeevi Tags: ORIGINAL CLINICAL SCIENCE Source Type: research