Macrocarquinoids A –C, new meroterpenoids from Sargassum macrocarpum

This study was conducted as a search for an AGE inhibitor from brown alga,Sargassum macrocarpum. Separation and purification were performed using AGEs inhibitory activity as an index, yielding isolation of 11 meroterpenoids, of which 3 were new compounds: macrocarquinoids A (1), B (6), and C (9). Their structures were elucidated using NMR spectral analysis with 2D techniques. All tested compounds showed AGEs inhibitory activity. Particularly, macrocarquinoid C (9) possessed the strongest activity (IC50: 1.0  mM) of isolated compounds. This activity was stronger than that of aminoguanidine (positive control).Graphic abstract
Source: Journal of Natural Medicines - Category: Drugs & Pharmacology Source Type: research