The innate immune effector ISG12a promotes cancer immunity by suppressing the canonical Wnt/ β-catenin signaling pathway.

This study reveals a mechanism underlying the anticancer effects of IFN. Some ISGs, as represented by ISG12a, may be useful in cancer therapy and prevention. The identified interrelations among innate immunity, Wnt/β-catenin signaling, and cancer immunity may provide new insight into strategies that will improve the efficiency of immunotherapy.
PMID: 32963356 [PubMed - as supplied by publisher]

Source: Cellular and Molecular Immunology - September 21, 2020 Category: Molecular Biology Authors: Deng R, Zuo C, Li Y, Xue B, Xun Z, Guo Y, Wang X, Xu Y, Tian R, Chen S, Liu Q, Chen J, Wang J, Huang X, Li H, Guo M, Wang X, Yang M, Wu Z, Wang J, Ma J, Hu J, Li G, Tang S, Tu Z, Ji H, Zhu H Tags: Cell Mol Immunol Source Type: research