Cancers, Vol. 12, Pages 2747: Prognostic Factors in Childhood Anaplastic Large Cell Lymphoma: Long Term Results of the International ALCL99 Trial
Cancers, Vol. 12, Pages 2747: Prognostic Factors in Childhood Anaplastic Large Cell Lymphoma: Long Term Results of the International ALCL99 Trial
Cancers doi: 10.3390/cancers12102747
Authors:
Lara Mussolin
Marié-Cecilé Le Deley
Elisa Carraro
Christine Damm-Welk
Andishe Attarbaschi
Denise Williams
Amos Burke
Keizo Horibe
Atsuko Nakazawa
Grazyna Wrobel
Georg Mann
Monika Csóka
Anne Uyttebroeck
Rafael Fernández-Delgado Cerdá
Auke Beishuizen
Karin Mellgren
Birgit Burkhardt
Wolfram Klapper
Suzanne D. Turner
Emanuele S.G. D’Amore
Laurence Lamant
Alfred Reiter
Wilhelm Woessmann
Laurence Brugières
Marta Pillon
With the aim of describing the long-term follow-up and to define the prognostic role of the clinical/pathological/molecular characteristics at diagnosis for childhood, adolescent and young adults affected by anaplastic large cell lymphoma (ALCL), we analyzed 420 patients aged up to 22 years homogeneously treated within the international ALCL99 trial. The 10-year progression free survival (PFS) was 70% and overall survival was 90%, rare late relapses occurred but no secondary malignancies were reported. Among clinical/pathological characteristics, only patients presenting a small cell/lymphohistiocytic (SC/LH) pattern were independently associated with risk of failure (hazard ratio = 2.49). Analysis of minimal disseminated disease (MDD), available for 162 patients, showed that both SC/LH pattern (hazard ratio = 2.4...
Source: Cancers - Category: Cancer & Oncology Authors: Lara Mussolin Mari é-Cecilé Le Deley Elisa Carraro Christine Damm-Welk Andishe Attarbaschi Denise Williams Amos Burke Keizo Horibe Atsuko Nakazawa Grazyna Wrobel Georg Mann Monika Cs óka Anne Uyttebroeck Rafael Fern ández-Delgado Cerdá Auke Beishui Tags: Article Source Type: research
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