Cancers, Vol. 12, Pages 2747: Prognostic Factors in Childhood Anaplastic Large Cell Lymphoma: Long Term Results of the International ALCL99 Trial

Cancers, Vol. 12, Pages 2747: Prognostic Factors in Childhood Anaplastic Large Cell Lymphoma: Long Term Results of the International ALCL99 Trial Cancers doi: 10.3390/cancers12102747 Authors: Lara Mussolin Marié-Cecilé Le Deley Elisa Carraro Christine Damm-Welk Andishe Attarbaschi Denise Williams Amos Burke Keizo Horibe Atsuko Nakazawa Grazyna Wrobel Georg Mann Monika Csóka Anne Uyttebroeck Rafael Fernández-Delgado Cerdá Auke Beishuizen Karin Mellgren Birgit Burkhardt Wolfram Klapper Suzanne D. Turner Emanuele S.G. D’Amore Laurence Lamant Alfred Reiter Wilhelm Woessmann Laurence Brugières Marta Pillon With the aim of describing the long-term follow-up and to define the prognostic role of the clinical/pathological/molecular characteristics at diagnosis for childhood, adolescent and young adults affected by anaplastic large cell lymphoma (ALCL), we analyzed 420 patients aged up to 22 years homogeneously treated within the international ALCL99 trial. The 10-year progression free survival (PFS) was 70% and overall survival was 90%, rare late relapses occurred but no secondary malignancies were reported. Among clinical/pathological characteristics, only patients presenting a small cell/lymphohistiocytic (SC/LH) pattern were independently associated with risk of failure (hazard ratio = 2.49). Analysis of minimal disseminated disease (MDD), available for 162 patients, showed that both SC/LH pattern (hazard ratio = 2.4...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research