Trichinella spiralis infection ameliorated diet-induced obesity model in mice.

Trichinella spiralis infection ameliorated diet-induced obesity model in mice. Int J Parasitol. 2020 Sep 20;: Authors: Ae Kang S, Ho Choi J, Baek KW, In Lee D, Jeong MJ, Sun Yu H Abstract Obesity is an increasingly prevalent disease worldwide, and genetic and environmental factors are known to regulate the development of obesity and associated metabolic diseases. Emerging studies indicate that innate and adaptive immune cell responses in adipose tissue play critical roles in the regulation of metabolic homeostasis. Parasitic helminths are the strongest natural inducers of type 2 inflammatory responses, and several studies have revealed that helminth infections inversely correlate with metabolic syndrome. Hence, this study investigated whether helminth infections could have preventative effects on high fat diet-induced obesity. Female C57BL/6 mice were maintained on either a low fat diet (LFD, 10% fat) or a high fat diet (HFD, 60% fat) for 6 weeks after Trichinella spiralis infection. The mice were randomly divided into four groups and were fed a normal diet, LFD, LFD after T. spiralis infection (Inf+ LFD), a high fat diet (HFD), or HFD after T. spiralis infection (HFD+inf). All groups were assayed for body weight, food efficiency ratio (FER), total body weight gain (g) / total food intake amount (g) fat weight, and blood biochemical parameters. Our data indicate that the HFD+inf group significantly reduced body weight gain, fat mass,...
Source: International Journal for Parasitology - Category: Parasitology Authors: Tags: Int J Parasitol Source Type: research