Benzylaminoethylureido-tailed benzenesulfonamides show potent inhibitory action against bacterial carbonic anhydrases.

Benzylaminoethylureido-tailed benzenesulfonamides show potent inhibitory action against bacterial carbonic anhydrases. ChemMedChem. 2020 Sep 23;: Authors: Ali M, Bozdag M, Angeli A, Carta F, Capasso C, Farooq U, Supuran CT Abstract A series of benzylaminoethylureido-tailed benzenesulfonamides was analyzed for their inhibition potential against bacterial carbonic anhydrases (CAs) such as VhCA α, β, and γ from Vibrio cholerae , and BpsCA β and γ-CAs from Burkholderia pseudomallei . Growing drug-resistance against antibiotics demands alternative targets and mechanisms of action. As CA is essential for the survival of bacteria, such enzymes have the potential for developing new antibiotics. Most of the compounds presented excellent inhibition potential against VhCA γ as compared to α and β, with K i s in the range of 82.5 - 191.4 nM. Several sulfonamides presented excellent inhibition against BpsCA β with K i s in the range of 394 - 742.8 nM. Recently it has been demonstrated that sufonamides CA inhibitors are effective against vancomycin-resistant enterococcus. Such data proved that CA inhibition of pathogenic bacteria may lead to a new class of antibiotics. PMID: 32966693 [PubMed - as supplied by publisher]
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research