Benzylaminoethylureido-tailed benzenesulfonamides show potent inhibitory action against bacterial carbonic anhydrases.

Benzylaminoethylureido-tailed benzenesulfonamides show potent inhibitory action against bacterial carbonic anhydrases. ChemMedChem. 2020 Sep 23;: Authors: Ali M, Bozdag M, Angeli A, Carta F, Capasso C, Farooq U, Supuran CT Abstract A series of benzylaminoethylureido-tailed benzenesulfonamides was analyzed for their inhibition potential against bacterial carbonic anhydrases (CAs) such as VhCA α, β, and γ from Vibrio cholerae , and BpsCA β and γ-CAs from Burkholderia pseudomallei . Growing drug-resistance against antibiotics demands alternative targets and mechanisms of action. As CA is essential for the survival of bacteria, such enzymes have the potential for developing new antibiotics. Most of the compounds presented excellent inhibition potential against VhCA γ as compared to α and β, with K i s in the range of 82.5 - 191.4 nM. Several sulfonamides presented excellent inhibition against BpsCA β with K i s in the range of 394 - 742.8 nM. Recently it has been demonstrated that sufonamides CA inhibitors are effective against vancomycin-resistant enterococcus. Such data proved that CA inhibition of pathogenic bacteria may lead to a new class of antibiotics. PMID: 32966693 [PubMed - as supplied by publisher]
Source: ChemMedChem - Category: Chemistry Authors: Tags: ChemMedChem Source Type: research

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Publication date: Available online 8 October 2020Source: Journal of Microbiological MethodsAuthor(s): Sohyun Cho, Lari M. Hiott, Tiffanie A. Woodley, Jonathan G. Frye, Charlene R. Jackson
Source: Journal of Microbiological Methods - Category: Microbiology Source Type: research
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Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
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Source: Emerging Infectious Diseases Journal - Category: Infectious Diseases Source Type: research
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Source: International Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Medical Imagery Source Type: research
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Source: Gastroenterology Research and Practice - Category: Gastroenterology Tags: Gastroenterol Res Pract Source Type: research
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Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
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Source: Current Opinion in Hematology - Category: Hematology Tags: HEMATOPOIETIC STEM CELL TRANSPLANTATION: Edited by Pavan Reddy Source Type: research
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Source: Iranian Journal of Microbiology - Category: Microbiology Tags: Iran J Microbiol Source Type: research
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Source: Medicine - Category: Internal Medicine Tags: Research Article: Observational Study Source Type: research
This study assessed the antimicrobial efficacy of synthesized zinc oxide nanoparticles produced using aqueous extracts of pomegranate leaves and flowers designated ZnO-NPs-PL, ZnO-NPs-PF. In the study, oxides of zinc were successfully employed to fabricate nanoparticles using extracts from leaves and flowers of pomegranate (Punica granatum). The nanoparticles obtained were characterized spectroscopically. X-ray diffractive analysis (XRD) revealed the elemental components and nature of the synthesized particles. The fabricated zinc oxide nanoparticle (ZnO-NPs) showed a crystalline structure. The morphology of the nanopartic...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
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