Transcription factor YY1 mediates epithelial –mesenchymal transition through the TGFβ signaling pathway in bladder cancer

In this study, we found Yin Yang 1 (YY1) is a critical regulator of EMT in bladder cancer. First, we showed that YY1 was upregulated in bladder cancer tissues than that in adjacent normal tissues. Then, we proved that YY1 promoted EMT of bladder cancer cells. Further experiments indicated that YY1 affected the EMT of bladder cancer through transforming growth factor-β (TGFβ) signaling pathway. Taken together, our study identifies YY1 as a key EM T driver in bladder cancer, suggesting it as a potential therapeutic target.
Source: Medical Oncology - Category: Cancer & Oncology Source Type: research