Genome-Wide Polygenic Score, Clinical Risk Factors, and Long-Term Trajectories of Coronary Artery Disease.

CONCLUSIONS: GPSCAD-a risk estimator available from birth-stratifies individuals into varying trajectories of clinical risk for CAD. Implementation of GPSCAD may enable identification of high-risk individuals early in life, decades in advance of manifest risk factors or disease.
PMID: 32957805 [PubMed - as supplied by publisher]

Source: Arteriosclerosis, Thrombosis and Vascular Biology - September 21, 2020 Category: Cardiology Authors: Hindy G, Aragam KG, Ng K, Chaffin M, Lotta LA, Baras A, Regeneron Genetics Center, Drake I, Orho-Melander M, Melander O, Kathiresan S, Khera AV Tags: Arterioscler Thromb Vasc Biol Source Type: research