Dose –Response Modeling: Extrapolating From Experimental Data to Real‐World Populations

In this study, a proba bilistic framework is developed that extends Brookmeyer's competing‐risks dose–response model to allow for variation in factors such as dose‐dispersion, dose‐deposition, and other within‐host parameters. With data sets drawn from dose–response experiments of inhalational anthrax, plague, and tularemia, we illustrate how for certain cases, there is the potential for overestimation of infection numbers arising from models that consider only the experimental data in isolation.
Source: Risk Analysis - Category: International Medicine & Public Health Authors: Tags: Original Research Article Source Type: research