National burden estimates of hospitalisations for acute lower respiratory infections due to respiratory syncytial virus in young children in 2019 among 58 countries: a modelling study

Publication date: Available online 21 September 2020Source: The Lancet Respiratory MedicineAuthor(s): You Li, Emily K Johnson, Ting Shi, Harry Campbell, Sandra S Chaves, Catherine Commaille-Chapus, Izzie Dighero, Spencer L James, Cédric Mahé, Yujing Ooi, John Paget, Tayma van Pomeren, Cécile Viboud, Harish Nair
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research

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This article describes the most characteristic and prevalent radiopaque and mixed lesions of the jaws and their imaging characteristics. Paget's disease, fibrous dysplasia, and rare sclerotic bone diseases of the maxillofacial bones are discussed elsewhere in this issue. Careful correlation of clinical presentation, panoramic radiographs, cone beam computed tomography, and histopathology are the cornerstones for appropriate lesion characterization. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Seminars in Musculoskeletal Radiology - Category: Radiology Authors: Tags: Review Article Source Type: research
This article reviews the most common disorders characterized by an increased bone density involving the craniofacial bones including fibrous dysplasia, Paget's disease of bone, meningioma with associated hyperostosis, and osteoma. Finally, typical examples of rarer sclerosing bone dysplasias are discussed as well.Emphasis is placed on imaging features and the differential diagnosis. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents  |  Abstract  |  Full text
Source: Seminars in Musculoskeletal Radiology - Category: Radiology Authors: Tags: Review Article Source Type: research
This article presents the current knowledge about this rare osteological disease. PMID: 33005994 [PubMed - as supplied by publisher]
Source: Zeitschrift fur Rheumatologie - Category: Rheumatology Authors: Tags: Z Rheumatol Source Type: research
Hypercalcemia of malignancy occurs in up to one third of patients at some point during the course of their advanced stage. The majority of them is caused by humoral hypercalcemia of malignancy due to systemic secretion of parathyroid hormone –related protein (PTHrP) by tumor cells. Extramammary Paget’s disease is a slow-growing cutaneous malignancy commonly limited to the epidermis of the anogenital region, but rarely becomes invasive and metastatic to distant sites. Herein, we report a 70-year-old male patient with metastatic extra mammary Paget’s disease. He consulted our hospital with altered conscious...
Source: Case Reports in Oncology - Category: Cancer & Oncology Source Type: research
Dominant mutations in valosin-containing protein (VCP) gene cause an adult onset inclusion body myopathy, Paget ’s disease of bone, and frontotemporal dementia also termed multisystem proteinopathy (MSP). The g...
Source: Orphanet Journal of Rare Diseases - Category: Internal Medicine Authors: Tags: Research Source Type: research
Anaemia is a common presenting feature among patients with chronic kidney disease (CKD) and it is associated with poor clinical outcomes and quality of life. It is not clear if growth differentiation factor-15...
Source: BMC Nephrology - Category: Urology & Nephrology Authors: Tags: Research article Source Type: research
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Source: Journal of Bone and Mineral Research - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
In this study, we conducted a mutation screening forSQSTM1 gene variants in 82 PDB patients and 100 control participants in Hungary. Mutations ofSQSTM1 were detected in 18 PDB patients (21.95%); associations between genotype and clinical characteristics were also analyzed. Altogether, six different exonic alterations, including two types of UTR variants in theSQSTM1 gene, were observed in our PDB patients. Similarly, to previous genetic studies on Paget ’s disease, our most commonly detected variant was the c.1175C >  T (p.Pro392Leu) in nine cases (four in monostotic and five in polyostotic form). We...
Source: Calcified Tissue International - Category: Orthopaedics Source Type: research
Abstract Pathological bone loss diseases (osteolysis, Paget's diseases) are commonly caused by the over differentiation and activity of osteoclasts. The Rho GTPases family members Rac1/2 (Rac1 and Rac2) have been reported for their special role in exerting multiple cellular functions during osteoclastic differentiation, which including the most prominent function on dynamic actin cytoskeleton rearranging. Besides that, the increasing studies demonstrated the regulating effects of Rac1/2 on osteoclastic cytoskeletal organization is through the GEFs member Dock5. Although the amount of relevant studies on this topic...
Source: Current Drug Targets - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Targets Source Type: research
This article describes the review of the bone, the activity of the calcitonin family of peptides, and the link between them. PMID: 32963524 [PubMed - as supplied by publisher]
Source: International Journal of Endocrinology - Category: Endocrinology Tags: Int J Endocrinol Source Type: research
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